Humanity was caught at a precipice a decade ago when the first gates—portals linked with other dimensions that harbor monsters immune to conventional weaponry—emerged around the world. Alongside the appearance of the gates, various humans were transformed into hunters and bestowed superhuman abilities. Responsible for entering the gates and clearing the dungeons within, many hunters chose to form guilds to secure their livelihoods.

Sung Jin-Woo is an E-rank hunter dubbed as the weakest hunter of all mankind. While exploring a supposedly safe dungeon, he and his party encounter an unusual tunnel leading to a deeper area. Enticed by the prospect of treasure, the group presses forward, only to be confronted with horrors beyond their imagination. Miraculously, Jin-Woo survives the incident and soon finds that he now has access to an interface visible only to him. This mysterious system promises him the power he has long dreamed of—but everything comes at a price.

The year is 2045, and artificial intelligence has undergone tremendous developments. Governments use them as weapons, engaging in never-ending warfare to sustain their economies. The mercenary group GHOST, headed by Major Motoko Kusanagi, is no stranger to this landscape. However, the rapid innovation of this technology causes a new threat to loom over the horizon.
Having left Public Security Section 9, Kusanagi and her group are involved in many operations worldwide related to these proxy wars. But a seemingly simple job of locating an arms dealer drags GHOST into a hidden conflict against cybernetically enhanced individuals, who have inexplicably gained extreme intelligence and physical abilities. Dubbed “post-humans,” their emergence sets off a chain of events leading to the reunion of Section 9. Armed with a new mission, it is up to Kusanagi and her reestablished team to prevent global chaos at the hands of these post-humans.