Thirty-seven-year-old Satoru Mikami is a typical corporate worker, who is perfectly content with his monotonous lifestyle in Tokyo, other than failing to nail down a girlfriend even once throughout his life. In the midst of a casual encounter with his colleague, he falls victim to a random assailant on the streets and is stabbed. However, while succumbing to his injuries, a peculiar voice echoes in his mind, and recites a bunch of commands which the dying man cannot make sense of.

When Satoru regains consciousness, he discovers that he has reincarnated as a goop of slime in an unfamiliar realm. In doing so, he acquires newfound skills—notably, the power to devour anything and mimic its appearance and abilities. He then stumbles upon the sealed Catastrophe-level monster “Storm Dragon” Veldora who had been sealed away for the past 300 years for devastating a town to ashes. Sympathetic to his predicament, Satoru befriends him, promising to assist in destroying the seal. In return, Veldora bestows upon him the name Rimuru Tempest to grant him divine protection.

Now, liberated from the mundanities of his past life, Rimuru embarks on a fresh journey with a distinct goal in mind. As he grows accustomed to his new physique, his gooey antics ripple throughout the world, gradually altering his fate.

Yoichi Isagi was mere moments away from scoring a goal that would have sent his high school soccer team to the nationals, but a split-second decision to pass the ball to his teammate cost him that reality. Bitter, confused, and disappointed, Isagi wonders if the outcome would have been different had he not made the pass. When the young striker returns home, an invitation from the Japan Football Union awaits him. Through an arbitrary and biased decision-making process, Isagi is one of three hundred U-18 strikers selected for a controversial project named Blue Lock.

The project’s ultimate goal is to turn one of the selected players into the star striker for the Japanese national team. To find the best participant, each diamond in the rough must compete against others through a series of solo and team competitions to rise to the top. Putting aside his ethical objections to the project, Isagi feels compelled to fight his way to the top, even if it means ruthlessly crushing the dreams of 299 aspiring young strikers.